Van Gerwen defeated fellow Dutchman Gian van Veen 8-5 in the final, capping off a dominant day at the Zenith Arena.
The three-time World Champion picked up the £30,000 winner's cheque after producing a series of outstanding performances, toppling Ryan Searle, Ryan Joyce, Josh Rock, and Van Veen on Finals Day to secure his first ranking title of 2025.
Van Veen fought back from a sluggish start to level the final at 2-2, responding with a sparkling 12-darter and a composed 76 checkout.
The next eight legs went with throw before Van Gerwen struck a crucial 13-darter to break for a 7-5 lead, before sealing the title on double 16.
"This definitely means a lot to me," reflected Van Gerwen.
"We all know where I'm coming from. I've been battling against myself recently.
"In the last few weeks I've been playing poorly. I know I have it in me, but you want to show it week after week, and I also put pressure on myself.
"This means the world to me. I needed this, I really needed this.
"We all know I’m in a tough position in the Premier League, but everyone who knows me knows that I never give up. I always keep fighting."
Classic MVG as Littler stunned
After enduring a rocky patch in recent months, Van Gerwen reasserted himself in emphatic fashion, lifting the German Darts Grand Prix trophy for the fourth time in his career.
In the semi-finals, Van Gerwen produced a storming finish, rattling off five consecutive legs to dispatch Josh Rock 7-2, setting up a rematch with World Youth Champion Van Veen - a repeat of their clash at last year’s Hungarian Darts Trophy.
Despite missing out on what would have been a landmark first European Tour title just days before his 23rd birthday, Van Veen could take plenty of positives from his weekend.
The rising Dutch star had charged into the final with impressive wins over Rene Eidams, Andrew Gilding, Martin Schindler, Ross Smith, and Luke Littler, including an electrifying semi-final where he averaged 110.81 to knock out the reigning World Champion.