Other eye-catching match-ups from the first round draw include World Cup winner Daryl Gurney facing a tricky test against dominant women's champion Beau Greaves, while Nathan Aspinall faces Lourence Ilagan and Stephen Bunting - impressive this season - taking on Poland's former UK Open quarter-finalist Sebastian Bialecki.
Luke Humphries, champion in 2024, will be up against Ted Evetts, a returning Simon Whitlock faces Connor Scutt, and Queen of the Palace Fallon Sherrock will look to upset the odds against Dave Chisnall.
Newly anointed world number one Littler heads the list of 40 top-seeded qualifiers who have booked their ticket courtesy of their position on the PDC Order of Merit, with the remaining players a mix of the next top 40-ranked names as well as regional qualifiers.
An expanded field of 128 players will head to Ally Pally in December for the biggest darts accolade available, competing for the Sid Waddell Trophy and a share of the £5 million prize fund.
Another first for the event sees all players entering the tournament at the first round stage, whereas top-ranked players previously entered in round two.
All first-round matches are contested over five sets.
The action begins on Thursday, December 11th, with Littler and Labanauskas headlining the night, with the traditional reigning champion rounding off the first night.
The tournament will then reach its climax on January 3rd, 2026, with the winner receiving a healthy £1,000,000.
PDC World Darts Championship draw in full:
(1) Luke Littler v Darius Labanauskas
Mario Vandenbogaerde v David Davies
(32) Joe Cullen v Bradley Brooks
Mensur Suljovic v David Cameron
(16) Damon Heta v Steve Lennon
Raymond van Barneveld v Stefan Bellmont
(17) Rob Cross v Cor Dekker
Ian White v Mervyn King
(8) Chris Dobey v Xiaochen Zong
Andrew Gilding v Cam Crabtree
(25) Luke Woodhouse v Boris Krcmar
Martin Lukeman v Max Hopp
(9) Gerwyn Price v Adam Gawlas
Lukas Wenig v Wesley Plaisier
(24) Ryan Joyce v Owen Bates
Krzysztof Ratajski v Alexis Toylo
(4) Stephen Bunting v Sebastian Bialecki
Richard Veenstra v Nitin Kumar
(29) Dirk van Duijvenbode v Andy Baetens
James Hurrell v Stowe Buntz
(13) Martin Schindler v Stephen Burton
Keane Barry v Tim Pusey
(20) Ryan Searle v Chris Landman
Brendan Dolan v Tavis Dudeney
(5) Jonny Clayton v Adam Lipscombe
Dom Taylor v Oskar Lukasiak
(28) Michael Smith v Lisa Ashton
Niels Zonneveld v Haupai Puha
(12) Ross Smith v Andreas Harrysson
Thibault Tricole v Motomu Sakai
(21) Dave Chisnall v Fallon Sherrock
Ricardo Pietreczko v Jose de Sousa
(2) Luke Humphries v Ted Evetts
Jeffrey de Graaf v Paul Lim
(31) Wessel Nijman v Karel Sedlacek
Gabriel Clemens v Alex Spellman
(15) Nathan Aspinall v Lourence Ilagan
Mickey Mansell v Leonard Gates
(18) Mike De Decker v David Munyua
Kevin Doets v Matthew Dennant
(7) James Wade v Ryusei Azemoto
Ricky Evans v Man Lok Leung
(26) Cameron Menzies v Charlie Manby
Matt Campbell v Adam Sevada
(10) Gian van Veen v Cristo Reyes
Alan Soutar v Teemu Harju
(23) Dimitri Van den Bergh v Darren Beveridge
Madars Razma v Jamai van den Herik
(3) Michael van Gerwen v Mitsuhiko Tatsunami
William O'Connor v Krzysztof Kciuk
(30) Peter Wright v Noa-Lynn van Leuven
Kim Huybrechts v Arno Merk
(14) Gary Anderson v Adam Hunt
Connor Scutt v Simon Whitlock
(19) Jermaine Wattimena v Dominik Gruellich
Scott Williams v Paolo Nebrida
(6) Danny Noppert v Jurjen van der Velde
Nick Kenny v Justin Hood
(27) Ritchie Edhouse v Jonny Tata
Ryan Meikle v Jesus Salate
(11) Josh Rock v Gemma Hayter
Niko Springer v Joe Comito
(22) Daryl Gurney v Beau Greaves
Callan Rydz v Patrik Kovacs