It was a well-fought battle between the two Englishmen, which lasted a touch over 41 minutes.
But it was also a comprehensive victory for 'Cool Hand' Luke, who never found himself in a losing position against Littler.
Humphries stormed to a 5-1 lead, but 'The Nuke' kept things competitive to pull back 6-5.
The duo then went blow-for-blow until Humphries stringed together the final three rounds for an 11-7 win.
It is the world number one's seventh major title.
Speaking after his victory, Humphries said: "I'm really proud because I didn't feel myself this week playing-wise.
"There's something Luke does to you, he really drives me and makes me want to be a better player. I enjoy playing him."
"These big games are what I live for, being a major champion is what I do it all for," Humphries added.
"If you go by stats, Luke is easily the best player in the world... but there's something about me that never gives up.
"He's made me a bit hungrier, practice more, try a bit harder... because if no one sticks with him, he's going to win everything. I believe we are the two best players in the world."
Sunday's results
Quarter-finals
Luke Littler 10-3 Mike De Decker
Scott Williams 3-10 Ross Smith
Connor Scutt 9-10 Dirk van Duijvenbode
Luke Humphries 10-5 Ryan Joyce
Semi-finals
Luke Littler 11-9 Ross Smith
Dirk van Duijvenbode 8-11 Luke Humphries
Final
Luke Littler 7-11 Luke Humphries