The Bills are coming into this AFC East matchup as 11.5-point favourites with a 2-0 record, following wins against the Baltimore Ravens and New York Jets.
They lead the entire NFL in total offence, ranking second in passing yards per game (284.0), rushing yards per game (166.0), and points per game (35.5). Their defence ranks 8th (1st in passing, 31st in rushing) and 22nd in scoring.
Meanwhile, the Dolphins are the exact opposite. Their defence ranks 26th overall (24th in passing, 25th in rushing) and 31st in scoring. Miami ranks 25th in total offence (15th in passing, 29th in rushing) and are tied for second-most in turnovers (4).
The Bills, on the other hand, are still just one of six teams to have yet to commit a turnover.
Buffalo has won six straight against Miami and have gone 12-2 against the Dolphins with Josh Allen as the starting quarterback.
As for injury reports, Buffalo will be without two key starters in linebacker Matt Milano (pectoral) and defensive tackle Ed Oliver (ankle). Defensive backs Taron Johnson (quad) and Jordan Hancock (shoulder) are both questionable, as is linebacker Shaq Thompson (hamstring/hand) - however, all three practiced this week.
Miami's Darren Waller (TE), Storm Duck (CB), and Ifeatu Melifonwu (S) have all been ruled out. Questionable players include Benito Jones (DT), Chop Robinson (LB), and Jaylen Waddle (WR) - all of whom practiced this week.
Now, let's get into our experts' picks!
They are a combined 5-3 in TNF picks, with Eric and Miguel going a perfect 2-0 so far, Paul going 1-1, and Henri at 0-2.
Eric - Bills 48-20 Dolphins
Buffalo is now just one of two teams so far this season to be at least double-digit point favourites. The other? Baltimore (-11.5) in Week 2 against the Browns - and they won 41-17. I expect the Bills to produce a similar result.
Miami took a tough loss to the Patriots at home in Week 2 and are on an unavoidable collision course to start the year 0-3 after a battle with the Super Bowl-contending Bills.
Maybe there's a universe out there where the Dolphins pull off a win this week - but it's not happening in this won. Prepare for another classic ugly Thursday night beatdown.
Miguel - Bills 38-20 Dolphins
This will be as difficult a road game for Miami as humanly possible. Everything seems to indicate, given what has happened in the first two weeks of the regular season, that Josh Allen and company will win easily.
They are a much better team than Miami in all regards. The only way for the Dolphins to get a win is for Tua Tagovailoa to connect with his receivers to try and keep up with the fast pace that the Bills usually set.
There are two options in this game: either Buffalo wins decisively, or Miami is inspired and the game is decided in the final moments with a high combined score - safe to say, I'm going with the former.
Henri - Bills 52-7 Dolphins
The Miami Dolphins team we have seen in the first couple of weeks of this season are nowhere near strong enough to compete with Buffalo - on any level whatsoever.
Josh Allen's Bills are one of the Super Bowl favourites for a reason will pull of a clear victory against the Dolphins here, never giving Miami a single shred of hope en route to the NFL's biggest win of the season.
Paul - Bills 34-13 Dolphins
It is not even gonna be a little bit close between the Bills and Dolphins, I'm afraid. Josh Allen put up a measly amount of yards against the Jets, and they still pummeled them thanks to one of the best run games in the league.
Tua Tagovailoa has been 'shocking' in the worst ways possible and will continue to 'shock' against Buffalo, who'll allow De'Von Achane to score Miami's only touchdown of the night.
We're at Highmark. It's prime time. It's Allen and the Bills. Football is football, but this can only really go one way.