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Flashscore's NFL Week 1 matchup picks

Philadelphia Eagles running back Saquon Barkley in the Kelley Green uniform
Philadelphia Eagles running back Saquon Barkley in the Kelley Green uniformMitchell Leff/Getty Images/AFP
The 2025 NFL season is just one day away and our experts sat down to make all of their Week 1 picks!

It all kicks off on Thursday, September 4th, when the Dallas Cowboys (+8.5) hit the road to face the reigning Super Bowl champion Philadelphia Eagles (-8.5). 

Then the Kansas City Chiefs (-3.5) and Los Angeles Chargers (+3.5) are heading to Sao Paulo, Brazil, for the league's first international game of the season on Friday, September 5th (read here for the full international schedule). 

Sunday night will be a rematch of last year's AFC Divisional Round as the Baltimore Ravens (+1.5) head north to take on the Buffalo Bills (-1.5). The last time these two teams met, Baltimore lost after failing to convert a crucial two-point conversion. But it's a new season and nobody knows who will come out on top. 

Monday night will see an NFC North showdown between the Minnesota Vikings (-1.5) and the Chicago Bears (+1.5). Minnesota won both matchups against Chicago last season and have taken eight of the last 10 matchups dating back to 2020. It's also worth noting that the Bears lost every home game in that span - but will that stop our experts from picking them this season?

And, before our picks, check out these other articles before the season begins:

10 bold predictions that will undoubtedly happen

10 players who need to prove everyone wrong

15 rookies to watch out for this season

Teams ready to turn things around

Teams destined to fall off in 2025

Division winner predictions

Super Bowl LX predictions

Now, here are the picks from our experts!

NFL Week 1 predictions
NFL Week 1 predictionsEric Himmelheber / Flashscore