The top three were involved in Copa del Rey action in midweek and also have the Champions League on their minds.
But while two is company and three is a crowd, Bilbao would love to gatecrash the party in LaLiga.
They thrashed visiting Valladolid 7-1 last weekend to extend their unbeaten league run to 16 games and, though they are still five points off third-placed Atletico, a win at the Madrid side on Saturday would be a massive boost to their title hopes.
They take on an Atleti outfit, who are in the middle of some titanic clashes with the top two.
Atletico played out a thrilling 4-4 draw at Barcelona in the Copa del Rey semi-final first leg and, three days after hosting Bilbao, they face a Champions League last-16 tie at Real Madrid.
Bilbao will have a little more time before their Europa League adventure continues when they visit AS Roma on Thursday, but they have injury worries ahead of facing Atletico.
While winger Nico Williams should recover from the flu, which kept him out of midweek training, midfielder Oihan Sancet is a major doubt.
Sancet is the club's top scorer this season with 13 league goals, six of those coming in the last four games, but was taken off in Sunday's win with a thigh muscle injury.
Atletico have 53 points, having drawn three of their last five games, and Diego Simeone's side know a win would not only deal a massive blow to Bilbao's hopes but could also see them overtake Barca and Real.
Barcelona top the standings
Barcelona lead the way on 54 points, a run of six successive wins taking them back to the top ahead of Real Madrid on goal difference, and they host Real Sociedad on Sunday before heading to Lisbon for Wednesday's Champions League game with Benfica.
Sociedad are ninth in the standings but just one point off sixth place, which would secure a Europa League spot.
Real Madrid beat Sociedad 1-0 on Wednesday in the other Copa del Rey semi-final first leg and face a tough test at Real Betis on Saturday, with the seventh-placed side coming into the match on the back of two consecutive wins.
Betis were boosted by their successful appeal of winger Antony's red card at Getafe last week, leaving the Brazilian clear to face Real Madrid, having scored three goals in six games since his arrival on loan from Manchester United in January.
Real Madrid, meanwhile, are still without the suspended Jude Bellingham, while fellow midfielder Dani Ceballos will miss the Betis game after picking up an injury in the Cup tie where manager Carlo Ancelotti rested several key players.
Kylian Mbappe should return to the Real side after missing the Cup game with a dental issue. The French forward scored both goals when Real defeated Betis 2-0 earlier in the season.