Abdoulaye Doucoure and Curtis Jones were both sent off late on in the reverse fixture in February, following a pattern it must be said.
That's because this fixture has produced more red cards than any other in Premier League history (25), and the Toffees’ 17 against Liverpool is also the most one team has against another in the competition.
The Reds can consolidate their position at the top of the Premier League table with three points that would place them 12 ahead of nearest rivals, Arsenal, with just eight games left to play.
A win for the Toffees would see them potentially jumping up to 13th place and leapfrogging Tottenham Hotspur and Manchester United in the process.
Liverpool have won five of the last six against Everton at Anfield
Liverpool have emerged victorious in their last three Premier League home games against Everton, each by a 2-0 scoreline, whilst they last won more consecutive home league Merseyside derbies between 1990 and 1994 (5).
Everton on the other hand will be looking to avoid defeat in both Premier League meetings with their arch-rivals for the first time since 2020/21. In that season, as this, the first meeting was a 2-2 draw at Goodison, with Anfield silenced in the return as the visitors walked away with a 2-0 win.
That defeat was Liverpool's only one against Everton at Anfield in the last 24 Premier League derby games there (W14 D9), including a run that's seen the hosts win five of the last six.
Four draws and one win for David Moyes' side since the first Merseyside derby of this season (13 draws overall in 2024/25) might give the impression that they're draw specialists.
It's hard to counter that argument too when you consider that 26 of the 65 Premier League meetings between Everton and Liverpool have seen the points shared, and only Chelsea vs Manchester United has finished level more often (27 times).
Jordan Pickford and his defenders will certainly need to be on their guard as Liverpool have scored at least twice in 26 of their 29 Premier League games to date in 2024/25, including each of their last nine in a row, and their last 12 in a row at Anfield.
If they're able to find the net at least twice again, they will become the first side in English top-flight history to score two or more goals in 27 of their opening 30 matches of a campaign - coincidentally a record that's currently held by Everton from their 1894-95 season (26).
Supporters of the Toffees might well take heart in the fact that their team are unbeaten in their last nine Premier League games (W4 D5) - last going longer without defeat in December 2013 under Roberto Martinez (10).
It's also their longest unbeaten run going into a league meeting with Liverpool since February 2010 (also nine games) - when they lost 1-0 at Anfield under David Moyes.
However, Moyes hasn't won any of his 19 Premier League away games against Liverpool. He's tied with himself for the joint-most times any manager has faced an opponent on the road without a single victory in the competition. His 19 visits to Stamford Bridge as an opposition manager also haven't resulted in a win.
As Everton boss, he's drawn six of his 11 league visits to Anfield (L5), including his last one in May 2013 (0-0).
Mo Salah is bound to have a say in proceedings given that he's been directly involved in eight goals in his last seven Premier League Merseyside derbies (6 goals, 2 assists).
The Egyptian King scored and assisted in this season's reverse fixture and the only players to score and assist in both of their Premier League matches against Everton in a single season are Chris Sutton in 1993/94 and Alan Shearer in 1994/95.
WIth 27 goals and 17 assists so far this season, Salah is way out in front of his teammates, and he might hope that the likes of Cody Gakpo (8G) and Darwin Nunez (5G) will weigh in with a strike or two of their own on Wednesday night.
Liverpool's No.11 does carry the attacking responsibility and burden with aplomb, though it's a sharp reminder of what life might be like from 2025/26 onwards if he takes the riches available in the Saudi Pro League or elsewhere.
Trent Alexander-Arnold's six assists this season places him second in that particular metric, but his injury will again rule him out for this one, and potential replacement Conor Bradley only has a 25% chance of playing some part.
Everton need joint top-scorer Beto to help fire them to glory
For the visitors, Iliman Ndiaye (6G) and Dominic Calvert-Lewin (3G) are both definitely out, meaning the goalscoring load will again fall to six-goal Beto, who opened the scoring in the game at Goodison.
One area where Everton have struggled is with their passing accuracy and whilst Liverpool might be expected to have the lion's share of possession, when David Moyes' side get their chance they need to ensure that crisp and clean passes result, something that they've not managed for the majority of the campaign.
Only a handful of players have a pass completion stat in the 80% range, with most around 70%+ and some (Pickford, Beto) even dipping near to 60%. Against the top teams, that's nowhere near good enough, and in front of a raucous and expectant Anfield, that's just going to pile the pressure on the Toffees, particularly when Liverpool are playing towards The Kop.
For a team that might pride themselves on their battling qualities, there too Everton are performing woefully. Only four players in the entire squad have won 60% or more of their duels with a direct opponent.
In terms of tackles won across the season, only Idrissa Gueye (66) and James Tarkowski (37) have emerged with the ball more than 30 times.
Tarkowski's late, late equaliser in the reverse fixture bookended the final Merseyside derby at Goodison better than anyone could've imagined, and how he would love to feature just as heavily to all but ensure Everton's Premier League safety.
