The Dutch giants travelled to Stamford Bridge but were quickly undermined by captain Kenneth Taylor’s 15th-minute red card.
Marc Guiu, 19, opened the scoring a couple of minutes later, becoming Chelsea’s youngest ever Champions League goalscorer.
Moises Caicedo then doubled their lead before midfield partner Enzo Fernandez made it 3-1 from the penalty spot.
Chelsea were then awarded a second penalty just before half-time, with Fernandez selflessly handing it to Estevao, 18, who scored and again broke the record Guiu set roughly 30 minutes earlier.
Chelsea started the second half as they ended the first, with Tyrique George, 19, making it 5-1 with the first Champions League goal of his career.
Maresca’s side are now the first club in the tournament’s history to have three teenagers score in the same game.